The present study was conducted to demonstrate the histological effects of ribavirin and/or sofosbuvir on liver and kidney of rats. Rats were treated with ribavirin (0.0227 mg/kg body weight), sofosbuvir (0.01 mg/kg body weight) and mixture of ribavirin and sofosbuvir for 12 weeks. Liver and kidney were stained with H/E stain. Liver tissue also stained with AgNORs stain. The results showed that no histological alteration or abnormal counts were observed after treatment with ribavirin and / or sofosbuvir. Also the count of AgNORs is non-significantly differs between the normal non-treated rats and those treated with ribavirin and/or sofosbuvir. The present study concluded that, treatment with ribavirin and / or sofosbuvir or both has no side effects on normal rats.
Abdallah, G., Elbakry, K., Elarabany, N., & Altamtam, S. (2016). Histological Study on the Effects of Sofosbuvir and/or Ribavirin on Normal Rats. Scientific Journal for Damietta Faculty of Science, 6(2), 144-149. doi: 10.21608/sjdfs.2016.194754
MLA
Gamal A. Abdallah; Kadry A. Elbakry; Naglaa F. Elarabany; Seeg A. Altamtam. "Histological Study on the Effects of Sofosbuvir and/or Ribavirin on Normal Rats", Scientific Journal for Damietta Faculty of Science, 6, 2, 2016, 144-149. doi: 10.21608/sjdfs.2016.194754
HARVARD
Abdallah, G., Elbakry, K., Elarabany, N., Altamtam, S. (2016). 'Histological Study on the Effects of Sofosbuvir and/or Ribavirin on Normal Rats', Scientific Journal for Damietta Faculty of Science, 6(2), pp. 144-149. doi: 10.21608/sjdfs.2016.194754
VANCOUVER
Abdallah, G., Elbakry, K., Elarabany, N., Altamtam, S. Histological Study on the Effects of Sofosbuvir and/or Ribavirin on Normal Rats. Scientific Journal for Damietta Faculty of Science, 2016; 6(2): 144-149. doi: 10.21608/sjdfs.2016.194754
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