Effect of 1-((2-hydroxyphenyl)iminomethyl)naphthalene-2-ol on a biochemical and hematological markers in Ehrlich ascites carcinoma bearing mice

Document Type : Original articles

Authors

1 Chemistry Department (Biochemistry Division), Faculty of Science, Damietta University, Egypt.

2 Chemistry department (Biochemistry Division), Faculty of Science, Damietta universities, Damietta, Egypt.

3 Chemistry Department, faculty of Science, Damietta University, Damietta, Egypt

Abstract

Background Some Currently, several Schiff base compounds are among the most essential building blocks for the creation of novel medications. The purpose of this assayment is the study of the anti-oxidant and anti-tumor effects of [1-((2-hydroxyphenyl) iminomethyl)naphthalene-2-ol] that is directed against the Ehrlich ascites carcinoma (EAC) cells seen in the male albino mice’s peritoneal cavity.
Methods Six groups of adult male Swiss albino mice were created: group I served as a negative control and received salt saline; group II received DMSO; group III received the tested substance; group IV, the EAC-bearing group served as the positive control.; mice were injected intraperitoneally (I.P.) with EAC cells (2.5x106 cells/m on day 1; group V served as a therapeutic group; mice were injected intraperitoneally (I.P) Study efforts were conducted about a some biochemical parameters.
Results Our results showed significant increase in biochemical parameters concerning the negative control group. Therapy with [1-((2-hydroxyphenyl)iminomethyl)naphthalene-2-ol] appeared to be effective against EAC and biomarker changes induced by EAC, as evidenced by the improvement of the same parameters.
Conclusion [1-((2-hydroxyphenyl) iminomethyl)naphthalene-2-ol] has good antioxidant and anti-tumor properties.

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Scientific Journal for Damietta Faculty of Science
Volume 14, Issue 3
December 2024
Pages 1-11

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